As of DonorWise 3.4.13, no workarounds are necessary to install DonorWise. The installation correctly handles installing the Microsoft .NET framework or Microsoft SQL Server Express when needed. The "fixer" is no longer necessary to run on Windows 10.
Screenshot of DonorWise on Windows 8!
Here's a screenshot of DonorWise running on Windows 8 (64-bit) using the SQL Server 2005 Express installed by the DonorWise installation: